Larger particles classification uses Raman spectroscopy

Published: 21-Feb-2008

German company rap.ID Particle Systems has introduced its latest generation of particle identification devices, which features a combination of sampling, fully automated image analysis, and Raman spectroscopy.


The new Advanced Single Particle Explorer can makes fast and precise measurement of size, count, and shape of over 10,000 particles from 5µm and larger.

With these results, particles are subsequently selected for identification. The user can identify around 400 particles an hour and begin determining potential contaminant sources in just a few gestures and with minimal training.

A conventional lab needs about a week to chemically identify the 20-40 largest contaminating particles once they receive your samples, which can cost up to €4,000, the company claim. The new Advanced Single Particle Explorer delivers the same results in 25 minutes.

Sample filtration can take three minutes by using the patented filtr.AID Membrane to load them into the machine, select the analysis mode, and hit start. Equipped with autofocus and automatic particle recognition, the device delivers complete particle size distribution analysis in one minute.

The technology is mostly used in the pharmaceutical industry toward to aid in the development and quality assurance of injectables, nasal sprays, and inhalants. Other applications include medical implant manufacturers, the automobile industry for improving electronic components production and fuel injection systems as well as in streamlining quality assurance.

Spectroscopic parameters (exposure and laser intensity) are determined by the system itself and the material composition is determined through comparison with the integrated database. Afterwards, the result is combined with the raw data (particle images, image recognition and material classification, spectra) in a 21 CFR Part 11 compliance document. A four-fold sample changer for routine studies is included.

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