Determining incubation regime article wins George Sykes Memorial Award

Published: 23-Jan-2015
Analysis

The Pharmaceutical and Healthcare Sciences Society (PHSS) awarded its 2014 George Sykes Memorial Award to Andrew Sage, Nadine Timas and David Jones of Rapid Micro Biosystems


In late December, the Pharmaceutical and Healthcare Sciences Society (PHSS) awarded the 2014 George Sykes Memorial Award to Andrew Sage, Nadine Timas and David Jones of Rapid Micro Biosystems for their scientific paper entitled, 'Determining incubation regime and time to results for automated rapid microbiology EM methods'.

The paper was published in the European Journal of Parenteral and Pharmaceutical Sciences 2014 Volume 19 Number 2. The PHSS presents the George Sykes Award for the best scientific article published in the journal over the course of the year. The International Review and Editorial Board casts the votes for the best piece.

The winning article abstract reads:

The use of growth-based rapid microbiology methods (RMMs) requires a time to result (TTR) to be determined with a defined incubation regime in order to obtain accurate results and take full advantage of potential time-savings provided by the RMM. A case study involving an environmental monitoring (EM) application to illustrate the simple process was performed using the automated Growth Direct System.

Recovery of a suite of in-house bacterial and mould isolates was examined at different incubation profiles to define the optimal regime to obtain the best recovery. Of the three, serial incubation at 22.5°C followed by 32.5°C was identified as optimal for the recovery of both the bacteria and mould. A TTR of 72h for this incubation profile was calculated, and the accuracy of the TTR was confirmed by comparison of the Growth Direct result with spread controls of the test organisms followed by equivalence testing versus the standard method using EM samples.

An alternative regime of a single temperature of 28°C was subsequently examined, and resulted in a 60h TTR, and comparable recovery versus the control spread plates indicating that this may be a viable alternative to serial incubation.

Click here to download the paper.

  • Companies:
  • Rapid Micro Biosystems
See more

You may also like

Manufacturing

Rapid Micro Biosystems raises $120m for contaminant testing platform

Read more
US-based fully automated microbial testing provided has raised funds to accelerate global expansion of its platform for use in pharmaceutical and vaccine manufacturing

Trending Articles

  1. You need to be a subscriber to read this article.
    Click here to find out more.
    Integrity testing of HEPA filters: A practical approach Filtering the air in aseptic process areas is critical to maintaining the cleanliness of the production environment. Jesus Casas provides tips to ensure HEPA filters are fit for purpose once installed in your facility
  2. Syntegon launches new "Settle Plate Changer" for automated viable monitoring Syntegon has patented its new Settle Plate Changer (SPC) for automated viable monitoring in the aseptic filling process
  3. You need to be a subscriber to read this article.
    Click here to find out more.
    Phoenix Controls launches dynamic airflow management solution for critical environments The platform uses specialised venturi valves and sensors to create automated airflow in response to environmental fluctuations in cleanrooms and other controlled environments
  4. Endotoxin control in depyrogenation tunnels Understanding the way glassware is depyrogenated and how high concentrations of endotoxin can be used to assess how well depyrogenation tunnels are functioning is key to quality control. Tim Sandle explains
  5. Microbiological monitoring: Adapting to new rapid methods regulatory demands Dr Wan Li Low from Cherwell takes a look at the shift towards Rapid Microbiology Methods (RMM) and their validation

Upcoming event

EMPQ Essentials and Real-World Strategies for Successful Cleanroom Qualifications

16 January 2025 | Virtual See all

You may also like

Manufacturing

Rapid Micro Biosystems raises $120m for contaminant testing platform

US-based fully automated microbial testing provided has raised funds to accelerate global expansion of its platform for use in pharmaceutical and vaccine manufacturing
Analysis

Rapid Micro Biosystems secures $60m

The investment will accelerate the company's continued global commercial expansion and product innovation
Analysis

Five ways to accelerate the microbial quality control process

Opportunities to accelerate microbial quality control testing should be of the utmost importance to manufacturers
Analysis

Avoid these four potential errors in the QC lab with automation

The traditional test for microbial colony enumeration is a proven method, but has several opportunities for errors, which can create costly investigations and user retraining
Analysis

RMM and commercial preparations: comparing performance with Growth Direct

Companies using commercially prepared organisms as part of their validation process should be aware of the differences as they plan their validations
Analysis

Getting Lean – the benefits of automation in the microbiology lab

At the PDA Berlin Event in February, Kevin Walsh, Technical Services Manager at Rapid Micro Biosystems, presented a poster entitled, 'Getting Lean: Benefits of Automation in the Microbiology Lab'
Analysis

Improving quality control microbial testing with automated, growth-based RMM

Rapid microbial methods approach the detection of growing colonies using different methods: not all systems are appropriate for every type of microbial test, and some systems may provide a rapid result, but will require additional steps or resources
Subscribe now