Glove ports are an essential tool for working with sensitive and potent materials.
These interfaces make it possible for operators to perform crucial work within contained environments such as isolators and restricted access barrier systems (RABS) without breaking containment. However, they are also prone to damage, which can lead to contamination.
An undetected leak in the glove interface can compromise the sterility of precious biopharmaceuticals, not to mention bring production to a halt while the leak is addressed.
Each facility will have its own detection protocols
In the case of radiopharmaceuticals or other potent materials, glove leaks also put operators at risk for radiation exposure.
Because a small hole can cause significant problems, operators must be trained to identify and address leaks in the glove port interface.
Each facility will have its own detection protocols that must be followed, but there are several best practices that operators should be familiar with to prevent, detect, and correct glove port interface leaks.
Visual inspection of the glove interface
The first line of defence against glove port leaks is regular visual inspection.
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