The Bosch subsidiary Pharmatec currently supports customers with suitable equipment during biotechnological drug production.
The pilot fermenter on show at Interpack is suited for both laboratory and industrial manufacture of pilot batches for cell cultivation, for instance for the use in cancer medication. Using different mixing technologies, it processes batches between eight and 50 litres. Via scale-up, batch sizes can even be increased to 200 litres.
New ALF 5000 stand-alone version for vials
For production-scale filling and closing of liquid pharmaceuticals Bosch showcases the ALF 5000 vial version for the first time. To date, customers could fill either ampoules or vials and ampoules on one machine. Now the proven platform is also available for vials only. The machine shown at Interpack is equipped with 100% in-process control and a carrying rake transport system, which provides an even gentler handling.
The ALF 5000 achieves an output of up to 600 containers per minute and can be combined with different barrier systems.
Barrier competence
Closed Restricted Access Barrier Systems (RABS) and the newly developed return air filter for highly potent products have been added to the portfolio.
In contrast to the commonly used safe change filters, which are situated in the technical area, the new return air filters are integrated into the machine.
This saves time and facilitates cleaning, because the highly potent substances are already filtered at point-of-use. Moreover, the filter exchange is particularly easy and safe: there is no contact between the operator and the contaminated filter medium.
We can provide customers with complete line concepts, tailored exactly to their requirements.
Containment and operator safety are also the focus of the downflow booth. Usually, the booth is used for manual weighing and dosing of powders.
By supplying fresh air from the ceiling and drawing dust away from the operator, he can work with the substances in the closed space without safety concerns. As a tradeshow highlight, the downflow booth is converted into a meeting room for customers.
CCI portfolio completed
With the KLV 1360, Bosch presents a new development for vacuum leak detection of rigid containers, which combines the highest inspection accuracy with maximum output.
Together with fully automated solutions for high-volume leak detection and laser-based headspace analysis (HSA), Bosch can now offer an entire portfolio of CCI technologies.
Benchtop devices for visual inspection, HSA and vacuum leak detection provide an additional overview of the broad inspection portfolio.
End-of-line assembly and packaging technology
The semi-automated MSA from the Bosch subsidiary Moeller & Devicon is designed for the assembly of multi-part single-use auto injectors or pens, which are used for the treatment of autoimmune diseases or in emergency care.
With its compact and hygienic design, the MSA platform is suited for the assembly of small volumes between five and 15 pieces per minute.
Standardised modules allow it to be upgraded for larger batches and fully automated production, offering drug producers the flexibility to adapt quickly to new market demands.
These lines can be further extended by adding secondary packaging solutions, as well as platforms and industry 4.0 technologies for serialisation and aggregation.
Further technologies, such as product and equipment sterilisation from the Bosch subsidiary Schoeller-Bleckmann Medizintechnik (SBM) complete the equipment portfolio for liquid pharmaceuticals.
“We can provide customers with complete line concepts, tailored exactly to their requirements,” said Christian Treitel, Head of Pharma Business Development at Bosch Packaging Technology.
“These lines can be further extended by adding secondary packaging solutions, as well as platforms and industry 4.0 technologies for serialisation and aggregation.”
Customised services for all maintenance strategies
Remote Service (a digital service now supported by a visualisation and chat feature, or the mobile version of the E-Portal) allow customers to receive targeted support regardless of their location.
Bosch will demonstrate virtual training concepts enabling manufacturers to acquire demand-oriented know-how for machine operation and maintenance.
The company will also illustrate how Preventive Maintenance Parts Kits and tailor-made maintenance agreements help to proactively minimise unplanned downtime.
Bosch at will be in hall 6, booth A30-C58.