Telemetry in rodent models of CNS disease
Detection of alterations in subclinical seizure activity, sleep disturbances and circadian rhythm during the course of CNS phenotype progression are valuable markers for evaluating lead compound efficacy and safety
Detection of alterations in subclinical seizure activity, sleep disturbances and circadian rhythm during the course of CNS phenotype progression are valuable markers for evaluating lead compound efficacy and safety. These physiological readouts appear often earlier than gross functional disturbances, and their assessment in response to novel CNS therapies facilitates timely and more subtle detection of both beneficial and potentially adverse effects.
In addition to recordings from the central nervous system, telemetric recordings can also be applied for monitoring peripheral autonomic nervous system functions and basic physiology of muscle and heart, which are sometimes impaired in CNS disorders.
Our telemetry system allows for monitoring a combination of measurements from EEG, ECG and EMG, temperature, locomotor activity and red light/light-dark cycle monitoring (circadian rhythm) in group housed mice and rats in their home cages. The system allows continuous recording of these readouts from hours to months, depending on the experimental design. Telemetry can also be applied to non-GLP safety studies where the focus is on animal monitoring after exposure to test articles in diseased or in naive animals.
For CNS studies, rats can be monitored with up to four biopotential leads (EEG, EMG, ECG and EOG). For mice, signals can be detected with up to two biopotential leads from a selection of EEG, ECG and EMG. In addition to these parameters, body temperature and activity are always monitored whenever recordings are made, providing an informative package of readouts that increases the number of value adding components to any type of a study.
